Manchester City take on Everton at the Etihad Stadium in the Premier League. City will be looking to respond after suffering a first league defeat of the season at Chelsea last week.
Bottom-of-the-table Fulham play host to in-form West Ham at Craven Cottage in the Premier League. The last meeting between the two London rivals ended 2-1 to Fulham back in 2014.
Southampton meet Arsenal at St. Mary's Stadium in the Premier League. This is Saints' first home game under new boss Ralph Hasenhuttl, while Arsenal are unbeaten in the league since August.
Old rivals meet at Anfield as Liverpool host Manchester United in the Premier League. Jurgen Klopp's side head into this still unbeaten in the league - can Mourinho's men stop them?